Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is associated with anovulatory infertility, menstrual disturbances and an adverse metabolic profile. Although the pathophysiology of PCOS remains unclear, dysregulation of gene expression has been previously shown in theca and granulosa cells. In this study, we used RNA-Sequencing to compare the transcriptomes of human granulosa cells from women with and without PCOS. Granulosa cells were retri...

Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is associated with anovulatory infertility, menstrual disturbances and an adverse metabolic profile. Although the pathophysiology of PCOS remains unclear, dysregulation of gene expression has been previously shown in theca and granulosa cells. In this study, we used RNA-Sequencing to compare the transcriptomes of human granulosa cells from women with and without PCOS. Granulosa cells were retri...